Flemoxin dose for adults. Flemoxin Solutab - instructions for use

Each home medicine cabinet should contain the minimum of medicines that will help in case of emergency. In addition to antiseptic drugs, there must certainly be broad-spectrum antibiotics, which is Flemoxin Solutab. So that your choice is not thoughtless, read the instructions before replenishing your first aid kit.

Flemoxin Solutab - instructions for use

This instruction for the use of Flemoxin Solutab is a simplified and supplemented analogue of the official description. It is recommended to consult a doctor before use. The summary of Flemoxin Solutab given below is not a self-medication guide and should be used for informational purposes only.

Flemoxin Solutab is a broad-spectrum antibiotic, a bactericidal drug that destroys bacteria: Streptococcus pyogens, S. pneumonae, Neisseria gonorrhoae, Clostrdium tetani, N. meningitidis, C. welchi, Staphylococus aureus, Moraxela catarralis, Bacillus anthracis, Listera monocytogenes, Staphylococcus spp, Helicobacter pylori, Haemofilus influenza.

Pharmacokinetic properties of the drug:

1. The absorption of the active substance occurs quickly in the stomach and intestines. The drug is absorbed by 93%, after two hours traces of the drug are found in the blood plasma.
2. Amoxicillin is distributed by binding to plasma proteins, penetrating into bone tissues, mucous membranes, sputum, intraocular fluid in the amounts necessary for therapeutic purposes.
3. Excretion occurs naturally with the help of the kidneys for an hour and a half. With renal disorders, the elimination time of amoxicillin in adults can increase up to 8-9 hours.

Flemoxin Solutab - composition

The composition of Flemoxin Solutab: amoxicillin trihydrate, which is synthesized by a semi-synthetic method, and is similar to penicillin. The complementary components of the drug are dispersed cellulose, microcrystalline cellulose, saccharin, vanillin, crospovidone, lemon flavor, tangerine flavor, magnesium stearate.

Flemoxin Solutab - indications for use

Indications for the use of the drug are as follows:

• with respiratory infections (bronchitis, sinusitis, tonsillitis);
• with infections of the digestive tract;
• with infections of the genitourinary system (cystitis);
• in diseases of the skin and soft tissues of infectious genesis.

The antibiotic is effective for otitis, stomatitis, fever, cough caused by bacteria sensitive to penicillins. The drug is produced in the form of tablets with a dosage of 125, 250, 500, 1000 mg. Tablets from white to yellowish color, oblong. The inscription with the company logo is clearly visible on the surface: on tablets with a dosage of 125 mg, “231” is written, 250 mg - “232”, 500 mg - “234”, 100 mg - “236”.

Flemoxin Solutab - dosage

It is important to know how Amoxicillin is taken depending on the age, disease and severity of the infection. Tablets should be taken orally without chewing on an empty stomach or after meals. The route of administration may be changed to a liquid form if, for example, a child cannot swallow a pill whole. For syrup, the tablet dissolves in a tablespoon of water, for suspension - in 100 ml of water. The dosage of Flemoxin Solutab must be prescribed by a doctor.

The use of the drug for bacterial infections of mild to moderate severity:

• The daily rate of 0.5-2.0 g is divided into two doses for adults.
• Treatment should be 5-7 days.
• Extend the course up to 10 days in case of streptococcal infections.
• In chronic, severe and recurrent diseases, the drug should be used in an increased dosage - 0.75-1 g in three divided doses.

For the complete destruction of Helicobacter pylori, the dose is adjusted to two grams per day, dividing it into two doses. For the treatment of acute gonorrhea, the dose is 3 grams at a time in combination with probenecid. The official instruction of Flemoxin Solutab recommends continuing treatment for another two or three days after all the symptoms of the disease have disappeared.

Flemoxin Solutab - contraindications

Contraindications to the use of the drug - an allergy to antibiotics of a similar group, hypersensitivity to minor components of the drug. Compatibility of amoxicillin with alcohol is zero. If you allow the simultaneous administration of an antibiotic and alcoholic beverages, then the drug will not work at the proper level and there will be a risk of the disease transforming into a chronic form.

Flemoxin Solutab - side effects

Side effects of the antibiotic are not common, however, when prescribing, they must be considered:

1. The digestive system in case of an overdose can react to the action of the drug by changing the taste of food, nausea, vomiting, diarrhea, stomatitis and glossitis. According to reviews, Flemoxin does not cause dysbacteriosis.
2. The urinary system reacts with the development of interstitial nephritis, crystalluria.
3. Hematopoietic system: there is a risk of leukopenia, neutropenia, thrombocytopenia and other pathologies.
4. Nervous system: increased anxiety, sleep disturbance, confusion, depression, headaches, dizziness.
5. Allergy. (For a detailed list of allergic manifestations, see the description of Flemoxin Solutab - official instructions).
6. Other side effects include vaginal candidiasis.

Flemoxin Solutab with angina

Flemoxin with angina acts purposefully on streptococci and staphylococci, which are the causative agent of this disease. Five types of angina are classified, the difference between which is in severity, and amoxicillin successfully copes with them. For the treatment of angina, it is better to take the drug along with B-complex vitamins, anti-inflammatory drugs.

Flemoxin Solutab for children

Flemoxin for children is the most suitable medicine. The child takes it inside with pleasure - the medicine is sweet and looks like a candy with the aroma of lemon or tangerine. It's better than injections. Children under 10 years old are given Flemoxin 250. To calculate the individual dosage, the patient's body weight is taken into account. The drug is calculated in the amount of 30-60 mg per kilogram of body weight. Children's dosage:

• 1-3 years - 0.125 g for three times or 0.25 for 2;
• 3-6 years - 0.25 g and 0.375 g three and two times a day.

Flemoxin Solutab during pregnancy

Flemoxin during pregnancy and lactation is prescribed in exceptional cases, if the expected benefit is greater than the likely risks. Amoxicillin in small quantities penetrates the placenta, and after the birth of a child, it can pass into breast milk. This can cause sensitization in infants, so it is not recommended for women to take the drug during breastfeeding.

The price of Flemoxin Solutab

The cost of the drug in Moscow and the region is presented in the table. The analysis carried out for other regions and the reviews left showed that the price in Moscow differs slightly from prices in other regions.

Region of the Russian Federation	Flemoxin Solutab (dosage/price)
Moscow and region
Republic of Crimea
Vladivostok
Sakhalin region

Flemoxin Solutab - analogues

Analogues of the drug with the active substance of the penicillin group and similar in action:

• Azlocillin - the active substance is azlocillin);
• Ampik - (ampicillin);
• Geopen - (carbenicillin);
• Isipen - (piperacillin):
• Penglob - (bacampicillin);
• Flucloxacillin - (Flucloxacillin).

Video: Flemoxin Solutab - application

With angina, in almost 95% of cases, antibacterial drugs are prescribed. High efficiency was shown by an agent belonging to the group of semi-synthetic penicillins - Flemoxin solutab.

The antibiotic is effective in all forms of angina, even with purulent, but it is especially important to emphasize that the medicine is suitable for the treatment of children and, if indicated, is prescribed to women during pregnancy.

Drug properties

Semi-synthetic antibiotic has a pronounced effect with a large number of pathogens. At the same time, the components have a mild effect on the entire body. The maximum effect can be achieved with the parallel appointment of this drug with drugs with antihistamine action and B vitamins.

Flemoxin with angina has one very important advantage. Most antibiotics have a negative effect on the digestive system, disrupting the microflora. For this reason, antibacterial agents, if possible, are not prescribed to children. If we consider Flemoxin, then it does not provoke the development of dysbacteriosis.

Application guide

Start taking the drug Flemoxin Solutab should only be prescribed by a specialist. Before this, tests for the sensitivity of bacteria that cause angina to antibiotics are mandatory, and contraindications for use are also excluded.

Considering that this antibiotic is used in the treatment of patients of all ages and can be prescribed to pregnant women, the dosage should be especially carefully approached in order to minimize the risks of side effects.

With tonsillitis, tablets are used, which are presented in various dosages. During the reception, you should especially carefully consider the dose indicated in the doctor's prescription, and the one that is prescribed on the package of the drug.

The duration of treatment for angina in adults is at least a week. With purulent inflammation, you should continue taking it for two weeks. At the same time, you can take the tablets with food, eating does not affect the effectiveness of the drug, swallowing whole or dissolving in water.

Dosage of the drug

The number of tablets taken is determined only by the doctor. In this case, the dose should not be underestimated, as this may cause the development of bacterial resistance to the active ingredients. The dosage of Flemoxin solutab is especially carefully calculated for angina in children. Depending on the severity of the condition and the age of the patient, the following dosage is average:

In chronic forms, as well as in the presence of other foci of infection in hard-to-reach places, such as sinusitis or otitis media that develop against a background of tonsillitis, it is recommended to use a dosage intended for the treatment of severe forms. In this case, the tablets are taken three times a day.

In some cases, the dosage is increased, but only as directed by the doctor. At the same time, in the presence of deviations from the kidneys, the dose should be halved. For children in the treatment of tonsillitis, it is recommended to crush the tablets or dissolve them in water.

Possible contraindications

In the treatment of tonsillitis, the first thing to be expected is an individual intolerance to the drug. Especially often this condition is observed when prescribing a medicine to people with pathologies such as colitis, kidney failure, liver pathology, as well as food or drug allergies.

Careful attention should be paid to the condition of women during pregnancy. When lactating, it is recommended to refuse the drug or stop feeding., since the active substance is excreted in small amounts with milk.

An increased risk of side effects is observed with the parallel use of the following drugs:

• laxatives;
• oral contraceptives;
• Medicines to reduce the acidity of gastric juice;
• Anticoagulants;
NSAIDs.

Side effects are manifested by symptoms such as frequent stools, bloating, nausea, abnormalities in the functioning of the kidneys. In more rare cases, rashes on the skin and itching are noted.

But in general, the drug is easily tolerated and, subject to the indicated dosage, does not cause any negative consequences and at the same time quickly alleviates the condition of patients with tonsillitis.

Flemoxin Solutab (lat. Flemoxin Solutab) is an antibacterial drug developed by the Japanese company Yamanuchi ( Yamanouchi Pharmaceutical Co).

The active substance is amoxicillin, which belongs to the semi-synthetic penicillins of the III generation.

It has a wide spectrum of bactericidal activity against gram-positive and gram-negative microorganisms. Available in the form of dispersible (soluble) tablets, providing a high degree of absorption.

It is used for infectious and inflammatory diseases of the upper respiratory tract, respiratory tract, digestive tract, genitourinary system, skin and soft tissues.

The discoverer of penicillins was the English microbiologist Alexander Fleming, who in 1929 described the antimicrobial properties of the waste products of the fungus Penicillium notatum. However, the scientist failed to isolate a stable extract of the mold culture.

In 1940, his work was continued by the British G. Flory and E. Chain. By assembling a group of researchers, they were able to obtain pure penicillin in quantities sufficient for further clinical trials. The performed experiments confirmed the high bactericidal activity of the found compound.

Due to the outbreak of the Second World War, it turned out to be impossible to organize the production of the drug in England, so the scientists approached the US government with a proposal to organize its mass production. In 1941, several American pharmaceutical laboratories produced the first batches of penicillin. Its production was finally put on stream by the end of 1944.

In the 50s. The first semi-synthetic antibiotics (methicillin, oxacillin, etc.) began to appear, exhibiting a broader antimicrobial activity in comparison with the natural drug. But all of them, like penicillin, could not withstand the acidic environment of gastric juice, therefore they were intended only for injection use.

In 1961, the first antibiotic suitable for oral administration was obtained - ampicillin. And in 1962, employees of the English corporation Beecham synthesized the second one - amoxicillin, which had greater bioavailability and fewer side effects. After a series of clinical trials, it became available to patients.

The term of patent protection for the original amoxicillin expired in 1987. The right to manufacture copies of it was received by various manufacturers.

In 1988, the Japanese company Yamanuchi developed amoxicillin in the form of soluble tablets. The use of dispersion technology made it possible to improve the pharmacokinetic characteristics of the antibiotic and reduce the frequency of negative reactions from the digestive tract. The drug entered the pharmaceutical market under the brand name Flemoxin Solutab.

Properties

International non-proprietary name: amoxicillin (English amoxicillin, abbr. amox).

IUPAC chemical name: (2S,5R,6R)-6-([(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino)-3,3-dimethyl-7-oxo-4- thia-1-azabicycloheptane-2-carboxylic acid trihydrate.

Structural formula:

Molecular formula: C16H25N3O8S

Molecular weight: 419.45

Amoxicillin trihydrate is a white crystalline powder, odorless, slightly soluble in water. Melting point - 403.3ºС. Boiling point - 743.2ºС (at 760 mm Hg).

Clinical Data

In clinical studies, the benefits of dispersible amoxicillin compared to its encapsulated and traditional tablet forms have been proven.

Work carried out in the 80-90s. (Wubbel L, Ahmed A, Muniz L, et al.), showed that Flemoxin Solutab is characterized by consistently high bioavailability and provides a stable therapeutic concentration in the foci of infection. When taken orally in any form (solid or dissolved), the drug was absorbed from the digestive tract by 93%, while conventional ampicillin capsules - only by 70%.

The maximum concentration of the active component in the blood when taking Flemoxin was achieved 2 times faster (30-60 minutes versus 1-2 hours). At the same time, due to the low residual concentration in the gastrointestinal tract, the drug had practically no irritating effect on the intestinal mucosa. Based on the data obtained, the researchers concluded that amoxicillin in a dispersed form has a higher efficacy and better tolerability than its traditional counterparts.

Composition, forms of release, packaging

Available in the form of dispersible tablets containing amoxicillin:

• 125 mg
• 250 mg
• 500 mg
• 1000 mg.

On one side of the tablets there is a digital designation ("231", "232", "234" and "236", respectively), on the other - a risk.

Sucrose, sodium chloride and gluten are excluded from the auxiliary composition, which facilitates the use of the drug in patients with diabetes mellitus, arterial hypertension and celiac disease.

Tablets are packaged in PVC blisters of 5 or 7 pieces. In cardboard packs, 2 or 4 blisters are packed.

Mechanism of action

Amoxicillin has a bactericidal effect. The drug inhibits the action of enzymes responsible for the synthesis of the main component of the bacterial cell walls - peptidoglycan. As a result, the microbial cell loses its ability to withstand the internal pressure of the liquid. Its walls swell and collapse.

The antibiotic remains stable in acidic environments.

Spectrum of antimicrobial activity

Amoxicillin is active against:

• some aerobic Gram-positive bacteria ( Streptococcus pyogenes, Strept. pneumoniae,Enterococcus faecalis, Listeria monocytogenes, non-penicillinase producing strains of Staphylococcus aureus),
• anaerobic Gram-positive flora (Clostridium tetani, Cl. Welchii),
• aerobic gram-negative bacteria (Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Salmonella spp., Shigella spp., Vibro spp., Neisseria meningitidis, Neisseria gonorrhoeae),
• anaerobic Gram-negative rods (Klebsiellaspp.).

The drug does not affect strains producing β-lactamase: Enterobacter spp., Proteus spp., Citrobacter spp., Serratiaspp., Morganellaspp., Pseudomonasspp. and Acinetobacter spp.

Metabolism and excretion

Each Flemoxin tablet consists of individual microspheres that begin to disintegrate only under the action of bicarbonates in the intestine. Thus, the active substance is released in the zone of maximum absorption. Eating does not affect the absorption of the drug.

Through the mucous membranes of the intestine, the antibiotic quickly and almost completely (92-94%) penetrates into the blood. The maximum plasma concentration is reached 30-60 minutes after ingestion. Up to 20% of amoxicillin binds to blood proteins.

The drug is distributed in most tissues of the body, creating consistently high concentrations in the skin, palatine tonsils, bronchial secretions, intraocular fluid, bile, urine, reproductive organs, bones and pleural fluid. It penetrates well through the placental barrier, poorly - through the blood-brain barrier.

Flemoxin is partially biotransformed in the liver to form inactive metabolites. It is excreted mainly in the urine. The half-life is 1-1.5 hours, in children under 6 months. - 3-4 hours, in persons with renal insufficiency - up to 8.5 hours.

Impaired liver function does not significantly affect the pharmacokinetics of amoxicillin.

Indications for use

Flemoxin Solutab is used for various bacterial infections caused by microflora sensitive to its action:

• infections of the upper respiratory tract and respiratory tract (otitis media, sinusitis, tonsillitis, pharyngitis, bronchitis, pneumonia),
• infections of the urogenital tract (cystitis, urethritis, cervicitis, gonorrhea, etc.),
• infections of the digestive tract (colitis, peritonitis, typhoid fever, salmonellosis, dysentery),
• infections of the skin and soft tissues (erysipelas, dermatoses, open wounds).

Contraindications

The drug is not prescribed for the following conditions:

• allergic reactions to penicillins or other beta-lactam antibiotics (cephalosporins, carbapinems),
• hypersensitivity to the auxiliary components of Flemoxin.

Carefully

Under the strict supervision of a physician, it is recommended to use the remedy for renal failure, lymphocytic leukemia, mononucleosis, and a history of inflammatory bowel disease (especially for antibiotic-associated colitis).

Pregnancy and lactation

The use of Flemoxin Solutab during pregnancy and lactation is acceptable if the expected benefit to the mother outweighs the possible risks to the child.

In the United States and Australia, amoxicillin is classified as safety category B (meaning that no adverse effects on the fetus were noted in animal studies).

Influence of inability to drive vehicles and other complex mechanisms

During the use of Flemoxin, there were no reports of its negative effect on the ability to drive vehicles from patients.

Dosage and administration

Flemoxin is taken orally, regardless of food intake. Tablets can be swallowed whole, chewed or dissolved in water to form a suspension (1 tablet per 100 ml of water) or syrup (1 tablet per 20 ml of water). Prepared liquid forms of the drug have a pleasant lemon-tangerine taste.

The dosage regimen is selected individually, taking into account the age and severity of the patient's condition:

• adults and children over 10 years of age are recommended to take 375-750 mg of the drug 2-3 times a day,
• children from 3 to 10 years old - 250-375 mg 3 times a day,
• children from 1 to 3 years - 125-250 mg 2-3 times a day.

For children under 1 year old, the daily dose is calculated based on body weight: 30-60 mg of amoxicillin per 1 kg of weight. The amount received is divided into 2-3 single doses.

In severe infections, it is preferable to take Flemoxin 3 times a day. The duration of therapy is 5-10 days. After the disappearance of the symptoms of the disease, the drug should be used for another 48 hours.

Side effects

Adverse reactions when taking Flemoxin are rare or extremely rare (in 1-10 cases out of 10 thousand). Among the reported events:

• nausea,
• vomit,
• taste disorders,
• diarrhea,
• colitis,
• increased levels of hepatic transaminases,
• decreased levels of platelets and neutrophils,
• interstitial nephritis,
• agranulocytosis,
• maculopapular (morbilliform) rash
• erythema,
• anaphylactic shock.

Dispersible tablets do not cause central nervous system disorders.

Overdose

Drug poisoning is manifested by nausea, vomiting and diarrhea. Treatment consists in washing the stomach, taking enterosorbents and rehydrants.

special instructions

Cross-resistance with other beta-lactam antibiotics may occur.

As with other penicillins, there are risks of superinfection.

If severe diarrhea occurs, Flemoxin should be discontinued immediately.

Transferred erythroderma is not an obstacle to prescribing the drug.

Interaction with other drugs

Acetylsalicylic acid, phenylbutazone, oxyphenbutazone and probenecid can slow down the excretion of amoxicillin from the body.

Antibiotics with bactericidal action enhance the antimicrobial effects of the drug. With combined therapy with sulfonamides or chloramphenicol (Levomycetin), the effect of amoxicillin is weakened.

Flemoxin reduces the effectiveness of oral contraceptives and, when taken with them, increases the risk of bleeding.

In clinical studies, no interaction of amoxicillin with allopurinol was observed.

Holiday conditions

On prescription.

Storage

In a dry place, at a temperature not exceeding 25ºС. Keep away from children. In pharmacies and medical institutions, Flemoxin Solutab is stored according to the conditions of list B.

Best before date

Manufacturer

The right to manufacture and sell the drug originally belonged to the Japanese corporation Yamanuchi ( Yamanouchi. The company was founded in 1923, and in the 80s. entered the top three of the Asian pharmaceutical industry.

Since 1988, Flemoxin has been produced by the European branch of Yamanuchi Europe ( YamanouchiEurope) located in the Netherlands.

In 2005, the corporation merged with the Japanese pharmaceutical company Fujisawa (Fujisawa Pharmaceutical) , changing its name to Astellas Pharma. The priority areas of the new enterprise were the development and production of drugs for the treatment of infectious, dermatological, cardiological, urological and oncological diseases.

Today, Astellas has more than 20 branches around the world, including the US, Europe, Russia, the Middle East and New Zealand. Its production facilities are based in Japan and a number of European countries. All factories are certified in accordance with international GMP standards. The drug Flemoxin Solutab continues to be produced on the same European site, but under the brand name of the updated company.

Countries in which it is implemented

As of 2015, Flemoxin Solutab is used in 9 countries:

• Russia,
• Ukraine,
• Belarus,
• Georgia,
• Egypt,
• Belgium,
• Netherlands,
• oman,
• Lebanon.

The product has been approved for sale by the local health institutes.

In Russia, Flemoxin was registered by the Ministry of Health of the Russian Federation in 1994.

Since 1990, all amoxicillin preparations have been on the WHO Essential Medicines List.

Analogues

At the moment, full-fledged copies of Flemoxin, produced using the Solutab technology, are not represented on the Russian market.

Analogues of the drug include amoxicillin preparations from other companies, which are produced in the form of:

• traditional tablets,
• film-coated tablets,
• capsules,
• granules and powders for the preparation of suspensions,
• prepared suspensions.

All of them have a similar spectrum of antibacterial activity and are prescribed for the same conditions. However, they differ from Flemoxin in terms of pharmacokinetic characteristics and safety profile.

In the Japanese product, the active substance is enclosed in microspheres, which protect it from the effects of gastric juice and ensure rapid release of the antibiotic in the small intestine. Thus, high absorption rates of the drug (92-94%) are achieved and its effect on the normal intestinal flora is minimized. From a clinical point of view, this means that Flemoxin has a stable therapeutic effect and practically does not cause negative reactions from the digestive system.

Amoxicillin film-coated tablets have the same high bioavailability and provide high tissue concentrations of the antibiotic. But unlike Flemoxin microspheres, they release the active ingredient in the digestive tract more slowly, so they often provoke dyspeptic disorders.

Traditional tablets, capsules and suspensions have an even lower safety profile. Their completeness of absorption in the intestine is 10-20% lower than that of Flemoxin, which explains the higher incidence of intestinal disorders. In addition, to maintain a stable antimicrobial effect, such drugs must be taken in higher (up to 3 g) daily doses.

Comparative characteristics of Flemoxin Solutab and some of its analogues:

Tradename	Manufacturer	Release forms	Bioavailability of the drug	Time to reach maximum blood concentration	Recommended doses and frequency of administration for adult patients	The frequency of adverse reactions from the digestive tract	Side effects from the central nervous system	Interaction with allopurinol
Flemoxin Solutab	Astellas Pharma (subsidiary, The Netherlands)	Dispersible tablets 125, 250, 500 and 1000 mg	94%	30-60 min	375-750 mg 2-3 times a day	Rarely and extremely rarely (in 1-10 patients out of 10 thousand)	Not observed	Not noted
Amoxicillin Sandoz	Sandoz (Austria)	Film-coated tablets, 500 and 1000 mg	Up to 90%	1-2 hours	250-1000 mg 3 times a day	Often (in 1-10 patients out of 100)	Dizziness, convulsions	When taken simultaneously, the likelihood of developing an "amoxicillin" rash increases
Ospamox	Biochemie (Austria)	Granulate for suspension (125mg/5ml and 250mg/5ml) 250 mg capsules 500 and 100 mg film-coated tablets	75-90%	1-2 hours	250-1000 mg 3 times a day	Often	Dizziness, hyperkinesis, convulsions	When taken at the same time, the risk of a rash increases.
Ecoball	AVVA-RUS (Russia)	Tablets 250 and 500 mg	75-90%	1-2 hours	500-750 mg 3 times a day	Often	Anxiety, confusion, dizziness, depression, seizures, insomnia, behavioral changes	When taken simultaneously, the risk of developing a rash increases.
Hikoncil	KRKA (Slovenia)	Capsules 250 and 500 mgPowder for drops for children 100mg/mlPowder for suspension (125mg/5ml and 250mg/5ml)	Up to 90%	1-2 hours	250-1000 mg 3 times a day	Often	Dizziness, depression, impaired consciousness, neuropathy, ataxia	When taken together, the risk of developing an "amoxicillin" rash increases
Amoxicillin DS	Mekophar Chemical Pharmaceutical Joint Stock Company (Vietnam)	Capsules 250 and 500 mg	70-80%	1-2 hours	500 mg 3 times a day	Often	Headache, dizziness, confusion, neuropathy, anxiety, sleep disorders, depression, seizures	When taken simultaneously, the risk of a rash increases.
Amosin	Sintez OJSC (Russia)	Capsules 250 mg Powder for suspension (in a sachet of 125, 250 and 500 mg) Tablets 250 and 500 mg	70-80%	1-2 hours	250-1000 mg 3 times a day	Often	Dizziness, convulsive reactions, neuropathy, depression	When taken together, the risk of skin rashes increases
Amoxicillin Hemofarm	Hemofarm (Serbia)	Capsules 250, 500 mg Granules for suspension	70-80%	1-2 hours	500-750 mg 3 times a day	Often	Anxiety, sleep disorders, behavioral changes, headache, neuropathy, dizziness, depression, convulsions	When taken together, the likelihood of skin rashes increases

Publication date: 2015-07-14
Last modified: 2020-01-31

Dear visitors of the site Farmamir. This article is not medical advice and should not be used as a substitute for consultation with a physician.

Flemoxin Solutab ® is one of the broad-spectrum oral antibacterial agents from the group. It has proven itself in various fields of medicine as an effective medicine against inflammation caused by pathogenic microflora. Often prescribed by doctors in case of infections of the respiratory tract, pelvic organs and digestive tract, skin, soft tissues. Suitable for both adults and children from the first years of life, has a minimum of contraindications and unwanted side effects.

The peculiarity of this drug is a water-soluble dosage form that increases the bioavailability of the active substance and makes it easier for patients of any age to take it. However, before taking it, you should definitely consult with a doctor of the appropriate profile: despite the low toxicity, which even allows you to prescribe Flemoxin Solutab ® during pregnancy, there are still restrictions on use and the risk of complications. The instruction will help to understand the specifics of the drug and responsibly approach the treatment.

Pharmacological group

The drug belongs to the group of penicillin antibiotics.

The composition of the drug

The active ingredient in dispersible tablets is the long-known semi-synthetic antibiotic penicillin, characterized by increased acid resistance and high absorption rate. It has been used in medicine for many years and has an excellent therapeutic effect in the antibiotic treatment of infections caused by the following pathogens:

• Gram-positive varieties of the family of staphylo- and streptococci (however, with Staphylococcus aureus, which produces the enzyme penicillinase, it is ineffective).
• Aerobic gram-negative meningo- and gonococci, Escherichia coli, Salmonella, Klebsiella and Shigella.

The bactericidal action of the antibiotic is based on the inhibition of the synthesis of peptidoglycan, a structural component of the cell wall of the pathogen, due to which it is destroyed and dies.

Release form Flemoxin Solutab ®

The manufacturer and patent holder is the well-known pharmaceutical company from the Netherlands Astellas Pharma Inc. The drug is available in the form of special dispersible (soluble) tablets. That is, you can take them either as usual - swallowing and drinking, or after mixing in a small amount of water. Each yellowish-white oval tablet has a transverse line and its own marking indicating the amount of active ingredient:

• "231" - this is the designation of a drug containing 125 mg of amoxicillin;
• "232" - corresponds to 250 milligrams of the antibiotic;
• "234" - 500 mg;
• "236" - 1 gram or 1000 mg (maximum dosage).

Photo of the packaging of Flemoxin Solutab ® in the form of tablets of 1000 mg

Other ingredients include microcrystalline and dispersible cellulose, crospovidone, citrus flavors, saccharin, vanillin, and magnesium stearate. Packed tablets are five pieces in a blister and, accordingly, 20 in a cardboard box. For the 125 mg version, a version of 2 blisters of 7 tablets each is also available.

Indications and contraindications Flemoxin Solutab ®

The list of conditions requiring careful use includes such physiological and pathological conditions of the body as:

• pregnancy;
• lactation period;
• Infectious mononucleosis;
• liver or kidney failure;
• lymphocytic leukemia;
• previously transferred diseases of the gastrointestinal tract (especially colitis provoked by antibiotic therapy);
• bronchial asthma;
• allergic diathesis.

The only strict ban on use is individual hypersensitivity to both penicillins (as well as cephalosporins and carbapenems), and to any of the auxiliary ingredients of the tablets.

Flemoxin Solutab ® - dosage for children

This drug can be given to a child from the first year of life, with little or no fear of side effects.

• up to a year - from 30 to 60 mg of amoxicillin per day for each kg of body weight (in 2-3 doses);
• at the age of 1 to 3 years - 250 milligrams twice or 125 three times a day;
• from three to ten years of age, a double dose of 375 mg or 250 mg three times a day is indicated.

The interval between doses of Flemoxin Solutab ® depends on the nature of the disease: the more severe it is, the more often you need to give the medicine (every 8 hours). If the disease recurs or its chronic form worsens, a daily dose of 3 doses should be taken.

As for the question of how many days an antibiotic should be given to a child, pediatricians advise doing this for 5-7 days (in case of infection with a Streptococcus pyogenes strain, at least 10). The best option is to continue taking it for 48 hours after all the symptoms of the disease disappear.

Dosage for adults

Absorption and assimilation of the drug do not depend on food intake, so Flemoxin Solutab tablets can be drunk at any time, simply by swallowing or chewing, or dissolving in water. For infections that are not too severe, children and adults who have reached the age of ten are usually prescribed a daily dose of 500-750 mg twice a day or three times 375-500. The maximum dose - 3,000 mg of amoxicillin per day - is indicated for severe conditions.

Gonorrhea in uncomplicated form is treated with 3 grams of an antibiotic in combination with 1 g of the anti-gout drug Probenecid, taken once. If the patient has a significant decrease in values ​​​​(less than 10 ml per minute) of creatinine clearance, then the dosage can be halved.

Side effects Flemoxin Solutab ®

Since this drug has only one strict contraindication, negative reactions of the body to the antibiotic are extremely rare. For example, from the side of the central nervous system, such cases have not been registered at all, and such side effects characteristic of many antibacterial agents as pseudomembranous colitis, interstitial nephritis, changes in the blood count, exudative or anaphylaxis are isolated.

A little more often, dyspeptic disorders (nausea, vomiting, taste distortions and diarrhea) are recorded, which quickly disappear. Allergy to Flemoxin Solutab ® in a child or adult patient is also rare and mostly in a mild form of a specific maculopapular rash. Dysbacteriosis practically does not manifest itself and quickly disappears after the end of the course of antibiotic therapy, even without maintenance treatment with probiotics.

Flemoxin Solutab ® during pregnancy and breastfeeding

Despite the fact that the active substance of the drug is completely absorbed by the body and is very quickly distributed throughout it, overcoming the placental barrier, no negative effect on the fetus has been identified. Thus, pregnant women can take the drug, but caution (that is, doing it strictly according to the doctor's prescription in the absence of alternatives) is necessary. The degree of penetration of the antibiotic into breast milk is negligible, so sensitization in infants is very rare. However, for safety reasons, breastfeeding can be suspended for the duration of treatment.

Flemoxin Solutab ® and alcohol - compatibility

The detailed annotation to the drug mentions the interaction of this ABP with other medicines. For example, NSAIDs, probenecid increase the concentration of the antibiotic in the blood plasma; laxatives, antacids and aminoglycosides slow down absorption, and bactericidal drugs act synergistically. Ethanol is not on this list, however, combining Flemoxin Solutab ® and alcohol is unacceptable for several reasons.

Side effects increase, especially dyspeptic disorders - nausea and vomiting. The load on hepatocytes (liver cells) increases many times over, which metabolize all chemical compounds, including alcohol and drugs that enter the bloodstream. The resulting toxins accumulate in the body and destroy it, causing hepatitis and cirrhosis. In addition, the diuretic effect of alcohol contributes to the rapid removal of the antibiotic from the body. As a result, antibiotic therapy does not have a therapeutic effect, and complications appear.

Diseases and their treatment

Each infection requires an individual approach to treatment. Only a qualified doctor can determine the type of pathogen, assess the severity of the patient's condition, the characteristics of his body, and make the appropriate appointment, so self-medication is unacceptable.

Flemoxin Solutab ® for sinusitis

The cause of inflammatory processes in the paranasal sinuses in most cases are strepto- and staphylococci. These pathogens are included in the spectrum of antimicrobial activity of amoxicillin, so preparations based on it are prescribed for sinusitis first. The specificity of the pharmacokinetics of Flemoxin Solutab ® allows it to be very quickly distributed to all organs and tissues, which is an indisputable advantage in case of inflammation of the paranasal sinuses.

Usually, relief occurs already on the second day of antibiotic therapy, and a week is enough for a complete cure. If the symptoms do not disappear within 48 hours, the disease is caused by a strain resistant to amoxicillin, which requires a change in the drug.

Flemoxin Solutab ® for otitis media

The treatment of inflammation of the middle ear with this drug has its own characteristics. By localization, the focus is difficult to access, so the duration of the course should not be minimal - this will help prevent relapses. In addition, the pill regimen must be three times a day: the daily dose prescribed by the doctor must be divided by three and taken every 8 hours. As a result, the optimal concentration of the antibiotic in the blood plasma and, accordingly, a quick recovery will be achieved.

About antibiotic treatment of otitis media

Flemoxin Solutab ® for pneumonia

The most common causative agent of pneumonia is Streptococcus pneumoniae, which is part of the spectrum of antimicrobial activity of aminopenicillins. Amoxicillin and drugs based on it are first-line drugs in treatment. They provide a therapeutic effect in 90% of cases, the course of treatment lasts from a week to ten days. The remaining 10% is a disease caused by strains that produce penicillinase, so antibiotic replacement is indicated.

Flemoxin Solutab ® for angina in children

Analogues and comparison

There are several antibacterial agents similar in antimicrobial activity and indications that can replace Flemoxin ®:

• Ecobol ® ;
• Amosin ® ;
• Amoxicillin ® .

However, the question of the appropriateness of such a step should be decided by the attending physician in order to take into account all possible risks and benefits.

Composition and form of release

in a blister 5 pcs.; in a box of 4 blisters (125, 250, 500, 1000 mg) or in a blister of 7 pcs.; in a box of 2 blisters (125 mg).

Description of the dosage form

White to light yellow dispersible tablets, oval in shape with the company logo and number on one side and a line dividing the tablet in half on the other side. Numerical designation: Flemoxin Solutab ® (125 mg) - "231"; Flemoxin Solutab ® (250 mg) - "232"; Flemoxin Solutab ® (500 mg) - "234"; Flemoxin Solutab ® (1000 mg) - "236".

Characteristic

Bactericidal acid-resistant broad-spectrum antibiotic from the group of semi-synthetic penicillins.

pharmachologic effect

pharmachologic effect- bactericidal, antibacterial.

Pharmacodynamics

Active against gram-positive and gram-negative microorganisms such as Streptococcus pyogenes, Streptococcus pneumonia, Clostridium tetani, C.welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (not producing beta-lactamase), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori. Less active towards Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae. Not active against microorganisms producing beta-lactamase, Pseudomonas spp., indole positive Proteus spp., Serratia spp., Enterobacter spp.

Pharmacokinetics

Suction

After oral administration, it is absorbed quickly and almost completely (about 93%), acid-resistant. After oral administration at a dose of 500 mg Cmax of the active substance in plasma is 5 μg / ml and is observed in blood plasma after 2 hours. With an increase or decrease in the dose of the drug by 2 times, Cmax in blood plasma also changes 2 times. Eating practically does not affect the absorption of the drug.

Distribution

Plasma protein binding is about 20%. Amoxicillin penetrates well into mucous membranes, bone tissue, intraocular fluid and sputum at therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in blood plasma by 2-4 times. In the amniotic fluid and umbilical vessels, the concentration of amoxicillin is 25-30% of its level in the blood plasma of a pregnant woman.

Poorly penetrates through the BBB, but with inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the concentration in the blood plasma.

Metabolism

Partially metabolized, most of its metabolites are inactive against microorganisms.

breeding

It is eliminated mainly by the kidneys, about 80% by tubular excretion, 20% by glomerular filtration. In the absence of impaired renal function, T 1 / 2 is 1-1.5 hours. In premature babies, newborns and children under 6 months - 3-4 hours.

Pharmacokinetics in special clinical situations.

T 1/2 amoxicillin does not change in violation of liver function.

In case of impaired renal function (Cl creatinine ≤15 ml / min), T 1/2 amoxicillin may increase and reaches 8.5 hours with anuria.

Indications for Flemoxin Solutab ®

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

respiratory infections;

organs of the genitourinary system;

organs of the gastrointestinal tract;

skin and soft tissues.

Contraindications

Hypersensitivity to the drug and other beta-lactam antibiotics.

Carefully:

polyvalent hypersensitivity to xenobiotics;

Infectious mononucleosis;

lymphocytic leukemia;

a history of gastrointestinal disease (especially colitis associated with the use of antibiotics);

kidney failure;

pregnancy;

lactation period.

Use during pregnancy and lactation

It is possible to prescribe the drug during pregnancy and lactation if the expected positive result from the use of the drug outweighs the risk of side effects. In small amounts, amoxicillin is excreted in breast milk, which can lead to the development of sensitization phenomena in a child.

Side effects

From the digestive tract: rarely - a change in taste, nausea, vomiting, diarrhea; in some cases - a moderate increase in the activity of hepatic transaminases; extremely rarely - pseudomembranous and hemorrhagic colitis.

From the urinary system: extremely rarely - the development of interstitial nephritis.

From the hematopoietic system: agranulocytosis, neutropenia, thrombocytopenia, hemolytic anemia are possible, but they are also extremely rare.

Side effects from the nervous system when using amoxicillin in the dosage form, dispersible tablets are not registered.

Allergic reactions: skin reactions, mainly in the form of a specific maculopapular rash; rarely - erythema multiforme exudative (Stevens-Johnson syndrome); in some cases - anaphylactic shock, angioedema.

Interaction

Probenecid, phenylbutazone, oxyphenbutazone, to a lesser extent acetylsalicylic acid and sulfinpyrazone, inhibit the tubular secretion of penicillins, which leads to an increase in the half-life and an increase in the concentration of amoxicillin in the blood plasma. Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin), when taken simultaneously, have a synergistic effect; antagonism is possible when taken with certain bacteriostatic drugs (eg chloramphenicol, sulfonamides). Simultaneous use with estrogen-containing oral contraceptives may lead to a decrease in their effectiveness and an increase in the risk of breakthrough bleeding). Co-administration with allopurinol does not increase the incidence of skin reactions, in contrast to the combination of allopurinol with ampicillin.

Dosage and administration

inside, before, during or after a meal. The tablet can be swallowed whole, divided into parts or chewed with a glass of water or diluted in water to form a syrup (in 20 ml) or suspension (in 100 ml).

Adults and children over 10 years old (for infections of mild and moderate severity) - 500-750 mg 2 times a day or 375-500 mg 3 times a day.

Children from 3 to 10 years old - 375 mg 2 times a day or 250 mg 3 times a day; from 1 to 3 years - 250 mg 2 times a day or 125 mg 3 times a day. The daily dose for children (including children under 1 year old) is 30-60 mg / kg / day, divided into 2-3 doses.

In the treatment of severe infections, as well as infections with hard-to-reach foci (for example, acute otitis media), it is preferable to take the drug three times.

In chronic diseases, relapses, severe infections: adults - 0.75-1 g 3 times a day, children - up to 60 mg / kg / day in 3 divided doses.

In acute uncomplicated gonorrhea - 3 g, once, in combination with 1 g of probenecid.

For infections of mild and moderate severity, the treatment is carried out for 5-7 days, for infections caused by Streptococcus pyogenes, for at least 10 days.

In the treatment of chronic diseases, severe infections, the dose of the drug should be determined by the clinical picture of the disease. The drug is continued for 48 hours after the disappearance of the symptoms of the disease.

For patients with Cl creatinine below 10 ml / min, the dose is reduced by 15-50%.

Overdose

Symptoms: nausea, vomiting, diarrhea, violation of water and electrolyte balance.

Treatment: gastric lavage, administration of activated charcoal, saline laxatives, correction of water and electrolyte balance.

special instructions

The presence of erythroderma in history is not a contraindication for the appointment of Flemoxin Solutab ® .

Cross-resistance with penicillins and cephalosporins is possible.

As with other penicillin drugs, superinfection may develop.

The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for discontinuation of the drug.

Prescribe the drug to patients with infectious mononucleosis and lymphocytic leukemia with caution, because. there is a high probability of the appearance of an exanthema of non-allergic genesis.

Storage conditions of the drug Flemoxin Solutab ®

At a temperature not higher than 25 °C.

Keep out of the reach of children.

Shelf life of the drug Flemoxin Solutab ®

5 years.

Do not use after the expiry date stated on the packaging.

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
A04.9 Bacterial enteric infection, unspecified	bacterial intestinal infections
	Gastrointestinal infections
	Intestinal bacterial infections
	Infections of the digestive tract
	Infectious and inflammatory diseases of the gastrointestinal tract
	Infectious disease of the gastrointestinal tract
	Intestinal infection
	Intestinal infection
	Acute intestinal infection
	Acute infectious disease of the gastrointestinal tract
	Acute intestinal disease with damage to the colon
J06 Acute infections of the upper respiratory tract, multiple and unspecified	Bacterial infections of the upper respiratory tract
	Pain in colds
	Pain in infectious and inflammatory diseases of the upper respiratory tract
	Inflammatory disease of the upper respiratory tract
	Inflammatory diseases of the upper respiratory tract
	Inflammatory diseases of the upper respiratory tract with difficult to separate sputum
	Secondary Influenza Infections
	Secondary infections in colds
	Flu conditions
	Upper respiratory tract infections
	Upper respiratory tract infections
	Respiratory tract infections
	ENT infections
	Infectious and inflammatory diseases of the upper respiratory tract
	Infectious and inflammatory diseases of the upper respiratory tract and ENT organs
	Infectious and inflammatory diseases of the upper respiratory tract in adults and children
	Infectious and inflammatory diseases of the upper respiratory tract
	Respiratory tract infection
	upper respiratory catarrh
	Catarrh of the upper respiratory tract
	Catarrh of the upper respiratory tract
	Catarrhal phenomena from the upper respiratory tract
	Cough in diseases of the upper respiratory tract
	Cough with a cold
	Fever with influenza
	SARS
	ORZ
	ARI with rhinitis
	Acute respiratory infection
	Acute infectious and inflammatory disease of the upper respiratory tract
	Acute common cold
	Acute respiratory disease
	Acute influenza-like respiratory disease
	Sore throat or nose
	Cold
	Colds
	Colds
	Respiratory infection
	Respiratory diseases
	Respiratory infections
	Recurrent respiratory tract infections
	seasonal colds
	Seasonal colds
	Frequent colds viral diseases
J22 Acute lower respiratory infection, unspecified	bacterial disease of the respiratory tract
	Bacterial infections of the lower respiratory tract
	Bacterial respiratory infections
	Viral respiratory disease
	Viral infections of the respiratory tract
	Inflammatory diseases of the respiratory tract
	Difficult sputum separation in acute and chronic respiratory diseases
	Respiratory tract infections
	Respiratory and lung infections
	Lower Respiratory Infections
	Lower respiratory tract infections
	Infectious inflammation of the respiratory tract
	Infectious diseases of the respiratory tract
	Infectious diseases of the lungs
	Infectious diseases of the respiratory system
	Respiratory tract infection
	Cough with a cold
	Lung infection
	Acute respiratory tract infection
	Acute respiratory viral infection
	Acute inflammatory disease of the airways
	Acute respiratory disease
	Respiratory infection
	Respiratory viral infections
	Respiratory syncytial virus infection in young children
	Respiratory diseases
	Respiratory infections
L08.9 Local infection of skin and subcutaneous tissue, unspecified	soft tissue abscess
	Bacterial or fungal skin infection
	Bacterial skin infections
	Bacterial soft tissue infections
	Bacterial skin infections
	Bacterial skin lesions
	Viral skin infection
	Viral skin infections
	Cellular inflammation
	Inflammation of the skin at injection sites
	Inflammatory skin diseases
	Pustular skin disease
	Pustular skin diseases
	Purulent-inflammatory disease of the skin and soft tissues
	Purulent-inflammatory diseases of the skin
	Purulent-inflammatory diseases of the skin and its appendages
	Purulent-inflammatory diseases of soft tissues
	Purulent skin infections
	Purulent soft tissue infections
	Skin infections
	Infections of the skin and skin structures
	Skin infection
	Infectious skin diseases
	Skin infection
	Infection of the skin and its appendages
	Infection of the skin and subcutaneous structures
	Infection of the skin and mucous membranes
	Skin infection
	Skin bacterial infections
	Necrotizing subcutaneous infections
	Uncomplicated skin infections
	Uncomplicated soft tissue infections
	Superficial erosion of the skin with secondary infection
	Umbilical infection
	Mixed skin infections
	Specific infectious processes in the skin
	Skin superinfection
M60.0 Infectious myositis	muscle abscess
	Soft tissue infections
	Myositis infectious
	Pyomyositis
	Specific infectious processes in soft tissues
M65 Synovitis and tendosynovitis	Inflammatory soft tissue disease
	Nonspecific tendosynovitis
	Acute tendovaginitis
	Edema syndrome in musculoskeletal diseases
	tendovaginitis
	Tendovaginitis (tenovaginitis)
	Tenosynovitis
	Tenosynovitis (tenosynovitis)
	tenosynovitis
M65.0 Abscess of tendon sheath	Soft tissue infections
M71.0 Bursal abscess	Soft tissue infections
M71.1 Other infectious bursitis	bacterial bursitis
	Bursitis infectious
	Soft tissue infections
N39.0 Urinary tract infection, unspecified	Asymptomatic bacteriuria
	Bacterial urinary tract infections
	Bacterial urinary tract infections
	Bacterial infections of the genitourinary system
	Bacteriuria
	Bacteriuria asymptomatic
	Bacteriuria chronic latent
	Asymptomatic bacteriuria
	Asymptomatic massive bacteriuria
	Inflammatory disease of the urinary tract
	Inflammatory disease of the urinary tract
	Inflammatory diseases of the bladder and urinary tract
	Inflammatory diseases of the urinary system
	Inflammatory diseases of the urinary tract
	Inflammatory diseases of the urogenital system
	Fungal diseases of the urogenital tract
	Fungal infections of the urinary tract
	Urinary tract infections
	Urinary tract infections
	Urinary tract infections
	Urinary tract infections
	Urinary tract infections
	Urinary tract infections caused by enterococci or mixed flora
	Urinary tract infections, uncomplicated
	Complicated urinary tract infections
	Infections of the genitourinary system
	Urogenital infections
	Infectious diseases of the urinary tract
	urinary tract infection
	urinary tract infection
	Urinary tract infection
	urinary tract infection
	urinary tract infection
	Urogenital tract infection
	Uncomplicated urinary tract infections
	Uncomplicated urinary tract infections
	Uncomplicated urinary tract infections
	Exacerbation of chronic urinary tract infection
	Retrograde kidney infection
	Recurrent urinary tract infections
	Recurrent urinary tract infections
	Recurrent urinary tract infections
	Mixed urethral infections
	Urogenital infection
	Urogenital infectious and inflammatory disease
	Urogenital mycoplasmosis
	Urological disease of infectious etiology
	Chronic urinary tract infection
	Chronic inflammatory diseases of the pelvic organs
	Chronic urinary tract infections
	Chronic infectious diseases of the urinary system